Wilma affects NFL, NCAA

first_imgMIAMI – Trying to beat the arrival of Hurricane Wilma in Florida, the NFL game between the Miami Dolphins and Kansas City Chiefs was moved up two days to tonight and will not be televised nationally. The game will begin at 7 p.m. EDT will be televised by CBS affiliates in South Florida and Kansas City. 160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set! “We are not extending the telecast to more markets because we want to adhere as closely as possible to the spirit of our long-standing policy not to conflict with high school and college football during their seasons (which means Friday night and Saturday),” NFL spokesman Greg Aiello said. It’s the third time since the start of the 2004 season that the Dolphins have rescheduled a home game because of a looming hurricane. Last year’s home opener against Tennessee was played a day early because of Hurricane Ivan, and the Dolphins’ game two weeks later with Pittsburgh was pushed back 7 hours by Hurricane Jeanne. center_img AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREWalnut’s Malik Khouzam voted Southern California Boys Athlete of the Week Meanwhile, the NHL’s Florida Panthers delayed any final decisions on their game Saturday night against Ottawa. The league and team officials planned to make that call today. Wilma’s pending arrival has affected virtually every athletic event scheduled for the Sunshine State this weekend. The Nationwide Tour’s Miccosukee Championship in Miami was canceled. The Georgia Tech-Miami and West Virginia-South Florida football games were postponed from Saturday. And tonight, Central Florida will host Tulane one day ahead of schedule. Wilma’s progress slowed a bit Thursday, and forecasters who originally thought the giant system could start a potentially devastating path across the Florida peninsula by Saturday now believe landfall in the Sunshine State might not occur until Sunday. Still, the storm was a Category 4 – severe enough that Gov. Jeb Bush declared a state of emergency. last_img read more

Round-up: Groves, Blues trialist, Hazard angers Spurs fans, Traore, Bees boss keen to finish above QPR

first_imgGeorge Groves will face fellow Briton Martin Murray at the O2 Arena on 25 June in an eliminator for the WBA super-middleweight title.Hammersmith’s Groves, 28, will fight on the same bill as Anthony Joshua’s first defence of his world heavyweight crown, against American Dominic Breazeale.Meanwhile, Brentford boss Dean Smith has declared that it would be “lovely” if his side finish the season above QPR.Rangers boss Jimmy Floyd Hasselbaink has tipped goalkeeper Matt Ingram to play in the Premier League. Armand Traore, who has not played a first-team match this season, played for QPR’s development side in a match against Colchester at Loftus Road tonight.Traore’s contract expires at the end of the seasonChelsea’s Under-21s were also in action. Yasin Ben El-Mhanni, a 20-year-old winger currently on trial with the Blues, scored in a 3-1 win at Middlesbrough.There continues to be speculation over Oscar’s future, with The Sun declaring that he hinted he is on his way out of Chelsea after the Brazilian ‘liked’ an Instagram post linking him with a move to Juventus.Fans on Twitter have been reacting – angrily, in the case of Tottenham supporters – to comments made by Chelsea’s Eden Hazard.Hazard scored twice against Bournemouth on SaturdayHazard, whose side face Spurs next Monday, has said that his club’s players do not want the north London side to win the title and that leaders Leicester deserve to be champions.In other news, Chelsea Ladies striker Fran Kirby has been named the Women’s FA Cup player of the round after her last-minute winner in the semi-final against Manchester City.And Steven Finn took three wickets but Middlesex’s bowlers struggled in windy conditions at Durham – where play was ended early after a snow flurry.Follow West London Sport on TwitterFind us on Facebooklast_img read more

How Molecular Trucks Build Your Sensors

first_imgIn the film Unlocking the Mystery of Life, biochemist Michael Behe, describing the intricacies of cells as we know them today, claimed that there are “little molecular trucks that carry supplies from one end of the cell to the other.”  If that seems an overstatement, you should look at the illustration in Cell June 11 in a Minireview called “Cilia and flagella revealed” by Snell, Pan and Wang.1  They not only describe trucks, they’ve found a train of boxcars and a whole crew of engineers, conductors and brakemen.    Cilia are appendages in the cell membrane that wiggle.  Everybody’s got them; they are ubiquitous in organisms, from bacteria to humans.  They line our respiratory tract, cleaning debris from our lungs.  They help our senses of smell and eyesight.  They are important for kidney function.  They may look simple, but only recently are scientists beginning to appreciate the complexity inside.  The authors begin:Our view of cilia has changed dramatically in the decade since Joel Rosenbaum and his colleagues discovered particles rapidly moving (2-4 micrometers/s) up and down within the flagella of the biflagellated green alga, Chlamydomonas (Kozminski et al., 1993).  Once cell biologists identified the cellular machinery responsible for this intraflagellar transport (IFT), it became clear that IFT is essential for the assembly and maintenance of cilia and flagella in all eukaryotes (Rosenbaum and Witman, 2002).  As we will outline in this brief review, the increased focus on these organelles has revealed that nearly all mammalian cells form a cilium, that the ciliary apparatus (a cilium plus its basal body) is somehow connected with cell proliferation, and that cilia play key (and as yet poorly understood) roles in development and homeostasis.Michael Behe in his book Darwin’s Black Box had a whole chapter on how cilia move (see these illustrations).  Recently, however, it has been appreciated that nonmotile cilia can also act as sensory probes.  The authors explain:Several properties of cilia recommend them for use as sensory transducers.  They project a cell type-specific distance from the cell body, making them exquisitely designed probes of the external milieu; both their overlying membrane and their cytoplasmic contents are relatively well isolated from the cell body, thereby offering all of the advantages of compartmentalization; the machinery for their assembly makes possible rapid, regulated transport of proteins between the organelles and the cell body; and, the assembly machinery seems exploitable for use directly in signaling pathways.Now that we know cilia are vital, it’s what goes on inside the narrow shafts during construction that is truly remarkable.  The authors mentioned IFT, or intraflagellar transport, a class of proteins that operate the transportation system.  During construction of a cilium or flagellum, parts need to be transported to the growing tip, or axoneme.  The IFT particles move up and down the inside walls of the shaft.  They describe how this works.  Watch for the word trucks:This flow of materials is driven by the IFT machinery.  Flagellar proteins synthesized in the cell body are carried to the tip of the flagellum (the site of assembly of the axoneme) by IFT particles, which are composed of at least 17 highly conserved proteins that form A and B complexes.  The plus end-directed microtubule motor protein kinesin II is essential for movement of particles and their cargo toward the tip (anterograde transport) of the flagellum, and a cytoplasmic dynein carries IFT particles back to the cell body (retrograde transport).  Thus, IFT particles function as constantly moving molecular trucks on a closed loop.  The tracks they travel on are the microtubule doublets of the ciliary/flagellar axoneme, microtubule motors power them, and the individual structural components (e.g., microtubule subunits, dynein arms, and radial spoke proteins) of the cilium/flagellum are their cargo.The construction system they describe next is reminiscent of a gondola at a ski resort, a series of ore carts in a mine shaft, or a conveyor at a rock quarry.  If you can picture architects building a tall structure like the Seattle Space Needle or the Eiffel Tower, imagine the engineers first devising a way to get the raw materials to the growing top.  Suppose they design a double trackway that can be extended in length as the structure grows.  Attached to this track are self-propelled dump trucks that can climb up the tracks, and another set of dump trucks that can climb down.  Each truck can carry a load of cargo.  New trucks are constantly added at the bottom, and old ones upon reaching the base are removed.  A pool of trucks and drivers is always available to traverse this vertical highway.  With this automated system running, workers at the top can take the cargo and build with it, and send waste products down the other side.  This two-way transportation system works not only to build the tower, but to dismantle it.Figure 2 presents a model for regulation of assembly, disassembly and for regulation of flagellar length.  In this model, the rate of particle entry and the number of particles per unit length are independent of length, and cargo loading is regulated.  Thus, in a rapidly growing flagellum (in the extreme case), every particle entering carries cargo, and every particle returning to the cell body is empty.  Once the proper length is attained, length control mechanisms engage.  At this steady-state length, the number of IFT particles entering and leaving per unit time is unchanged, but the proportion of cargo-loaded IFT particles that enters the flagella comes to equal the proportion of cargo-loaded IFT particles that leaves the flagellum.  In a disassembling flagellum, the situation is reversed from that of a growing flagellum, and (in the extreme case) every particle that enters the flagellum is empty and every particle that leaves the tip is full.  Thus, by regulating cargo binding to particles at both the base and the tip, and by controlling of assembly and disassembly of axonemal components at the tip (presumably driven by mass action and regulatory proteins), cells specify assembly/growth, steady-state length, or disassembly/resorption.The diagram in their figure shows what look like little ore-carts climbing up to the tip and back.  The authors describe next how these tall structures function not only as oars and outboard motors, but as chemical antennae.  Experiments have “called to the attention of cell biologists the under-appreciated but hardly insignificant role of cilia in sensory transduction.”  Here are some of your body parts that depend on these miniature probes that extend out from the cell into the surrounding environment, sensing what’s out there:Humans experience the environment through cilia in major sensory organs.  The outer segments of retinal rod cells are modified, nonmotile cilia, replete with photoreceptors for interacting with light; and the odorant receptors in the olfactory epithelium are peppered over the surface of the cilia of olfactory neurons.  Moreover, almost every mammalian cell contains a solitary cilium, called a primary cilium, whose most likely function is in signaling (Pazour and Witman, 2003).  For example, many of the neurons in brain contain primary cilia, some of which express receptors for somatostatin and serotonin (Pazour and Witman, 2003).  Perhaps the most striking example of the importance of primary cilia in homeostasis [i.e., dynamic equilibrium] comes from work on the epithelial cells of the collecting tubules in the kidney.  The primary cilium on each renal tubule cell functions as a flow sensor both in vivo and in MDCK cells in vitro.  Bending the cilium causes a large, transient increase in intracellular calcium concentration and a consequent alteration in potassium conductance (references in Boletta and Germino [2003]).Each of these cilia, and many more, are constructed by this molecular transportation system.  How many parts are involved in building a cilium?  If this system were magnified a hundred million times, children might find this the ultimate Lego toy:New proteomic and genomic studies may finally provide a platform for discovery of most of the as yet unidentified genes that encode ciliary/flagellar proteins.  A proteomic analysis of the axoneme of human cilia identified over 200 potentially axonemal proteins (Ostrowski et al., 2002).  Several of the proteins were previously identified as being in the axoneme, but many have no homologs or are of unknown function.(That would be over 200 different kinds of pieces, kids, and a lot of each.)  From genomic studies, they estimate it would require at least 362 genes to build a motionless cilium, and “more than 400-500 genes that are predicted to be needed for forming and regulating the ciliary apparatus”  One team measured the proteome (set of proteins) required to build the basal body (the bottom foundation of the structure) and flagellum to consist of 688 genes.  “There is no doubt,” they say, “that the FABB [flagellar and basal body] proteome represents an incredibly rich resource.”    Failure of cilia and flagella to develop properly are implicated in many diseases (see “Don’t mutate this gene, or else” in the 10/01/2003 headline).  Even some human obesity disorders might be traced to ciliary breakdown, as well as hypertension, diabetes and other “seemingly unrelated clinical problems”.    The authors do not speculate on how such a complex system with so many parts might have evolved, other than to assume that it did: for instance, “Paralogs of other mitotic proteins have also evolved to play roles in cilia.”  They also claim that plants unevolved them: they seem to have lost the 400-500 genes needed for building cilia or flagella, if they ever had them.  The authors examine studies in comparative genomics to determine how many of the cilia/flagella genes are ancestral, going back to the original machinery in the simplest alga or bacterium.  One study compared the IFT genes in several organisms with those in fruit flies:Using a large number of genomes provided stringent criteria and identified 187 candidate ancestral ciliary genes.  Sixteen are conserved in all ciliated organisms examined and absent in all nonciliated organisms; 18 are present only in organisms with motile cilia; 103 are common to organisms that utilize only conventional ciliogenesis; and 50 are shared only by organisms that form motile cilia in the ciliary compartment.Other studies are cited; 67% of the basal body genes in green algae and 90% of their flagellar and IFT genes were present in the full FABB proteome.  It appears, therefore, that this transportation system evolved early on, if it did, and has not changed much since.1William J. Snell, Junmin Pan, and Qian Wang, “Minireview: Cilia and Flagella Revealed: From Flagellar Assembly in Chlamydomonas to Human Obesity Disorders,” Cell, Vol 117, 693-697, 11 June 2004.Although this is a headlines service, sometimes we need to give enough detail to show just what the Darwinians are up against in the age of molecular biology.  As Michael Behe said in the film, scientists in Darwin’s day thought the cell was just a blob of protoplasm, not much different than a piece of jello.  Now, here is just one example of hundreds of complex systems in the cell that could drive the point home that a cell is a sophisticated factory of molecular machines running off self-correcting programmed instructions (and that is a simplistic understatement).  These authors admit that the intraflagellar transport system was already functional in green alga and bacteria, with no precursors.  The genes for the most part have changed little or none all the way to humans.  Even taking their most optimistic claim that 18 genes for motile cilia might be ancestral, when you consider that getting just one of them by chance is astronomically improbable in the best of all possible worlds (see online book), an honest evolutionist must surely throw up his hands in utter despair to believe that time and chance could produce such wonders.    Wouldn’t it be fun to take this knowledge in a time machine back to 1859 and show it to Charlie and his bulldog?  Actually, it would be cruel.  Chuck was already plagued by an upset stomach, and this would be like giving him a gallon of ipecac with free lifetime refills.(Visited 12 times, 1 visits today)FacebookTwitterPinterestSave分享0last_img read more

Naomi Ruele: Botswana’s Olympic medal swimming hopeful

first_img15 July 2016Meet Naomi Ruele, #Botswana’s first Olympic swimmer #TeamBotswana #Rio2016 ?? pic.twitter.com/33kwCaIH0B— Botswana (@Botswana) July 13, 2016Botswana is going Olympics-mad over its new swimming sensation, Naomi Ruele. The 19-year-old is the first swimmer from Botswana to qualify for the Olympics.Ruele, who currently swims for Florida International University in the US, qualified for the Rio Games in March this year, setting a personal best of 26.07 seconds in the 50m freestyle qualifier.During her time in the US, Ruele has won seven gold medals at the most recent C-USA Championships, the country’s top collegiate swimming competition. She set two records and was the top swimmer of the event.Ruele was recently named the Junior Female Sportsperson of the Year by the Botswana National Sports Council. It noted her remarkable achievements in the pool as well inspiring young Batswana to take an interest in the sport.Swimming Sensation Naomi Ruele Bags 7 Medals! –> https://t.co/0I9jOSAbGG #BotswanaYouthMagazine pic.twitter.com/yEjsX5VOIu— Botswana Youth Mag (@BotswanaYouth) March 17, 2016She will join the rest of the Botswana Olympic team made up of current African Games 400m champion Isaac Makwala and London Olympics 2012 800m silver medallist Nijel Amos.For the first time Botswana will have more than one female in their Olympic team. Track athletes Lydia Jele and Christine Botlogetswe will also join Ruele in Rio de Janeiro. Until now, 400m sprinter Amantle Montsho had been the only female Batswana Olympian, competing at the 2004, 2008 and 2012 Games.Heats for the Rio 2016 50m freestyle event begin on 11 August 2016 at the Barra da TijucaAquatics Stadium.Source: This is AfricaWould you like to use this article in your publication or on your website?See: Using SouthAfrica.info materiallast_img read more

What’s Behind The Public Shaming of Reddit’s King Troll Violentacrez?

first_imgfruzsina eordogh A Comprehensive Guide to a Content Audit When Gawker reporter Adrian Chen publicly outed troll and influential Reddit user Violentacrez as Michael Brutsch two weeks ago in what many are calling the “best story of the Web,” he changed the nature of the Internet forever. The resulting journalist-sanctioned public shaming:1. Highlighted how ignorant the media is of Internet culture.2. Forced the Internet’s core psyche, sometimes referred to as the “hive mind,” to mature from a teenage boy to a relatively respectful young adult almost overnight.3. Legitimized digital lynch mobs. The Seduction Of A Public ShamingOur technology may have evolved, but our attitudes have not: Nothing pleases humanity more than a good public shaming. Instead of pelting rotten tomatoes at a man locked in the town square stockade, society’s “sinners” are now paraded on national television, courtesy of Anderson Cooper, and branded with a scarlet “T.” (Just Google “Michael Brutsch” if you don’t know what I mean.)Brutsch is now the physical face of the most hated thing on the Internet: the Troll. That anonymous person who goes out of his way to provoke a response. While few people understand what trolls actually are, where they came from and why they do what they do, it is generally accepted that they are the scum of the Web. Hating on them unconditionally is not just acceptable, it’s encouraged, as Cooper implied by calling Brutsch a sad “little person,” sitting “alone in his room, typing on his keyboard, interacting with people he doesn’t even know.” Cooper did stop short of calling him a “neckbeard,” but other outlets have not –  he’s been called a “monster,” and even falsely tied to the suicide of Amanda Todd and the “capper” community. Brutsch didn’t create the act of trolling, nor was he the original or most notorious troll. (Brutsch might not even be a troll, as tech culture journalist Xeni Jardin pointed out.) Nor is Brutsch the first man to have an offensive porn collection, or the first man to sexualize children. Regardless, Brutsch will be made an example of, dammit, because we the media (or as Forbes Kashmir Hill called it, “The Internet Cool Kids”) are sick and tired of these vile human beings mucking up our Internet! Never mind that the same media leverages these same transgressors to drive pageviews – all cloaked in hand-wringing and faux outrage (an act Reddit itself is guilty of) . And, of course, the same said media also sexualizes children.   Guide to Performing Bulk Email Verification Related Posts Tags:#Trolls center_img The Dos and Don’ts of Brand Awareness Videos Trolls Are Easy TargetsCalling Brutsch’s transgressions “vile” isn’t an overstatement – his stuff was downright disgusting. Brutsch had his hands in some of the most controversial subreddits, including /r/incest, /r/misogyny, /r/beatingwomen, /r/chokeabitch, /r/Jewmerica, /r/Jailbait, /r/niggerjailbait, /r/rapebait, /r/picsofdeadkids and /r/creepshots, just to name a few. If you are offended by those titles, that’s the point of a Troll: Brutsch’s online behavior is so offensive that anyone that wants to be considered a respectable member of society has no choice but to oppose his behavior.As Chen describes trolling in his unmasking piece: “A troll exploits social dynamics like computer hackers exploit security loopholes, and Violentacrez calmly exploited the Reddit hive mind’s powerful outrage machine and free speech values at the same time.” If “troll” wasn’t the hot button word of the year, we’d be calling Brutsch’s digital binders of scantily clad or beaten women “performance art.”Whitney Phillips, a scholar studying Internet trolling culture, put it another way, calling trolls “cultural scavengers” that “engage in a process I describe as cultural digestion: They take in, regurgitate, and subsequently weaponize existing tropes and cultural sensitivities.” Trolls don’t engage in this sort of behavior alone or in a vacuum, Phillips said. Rather, they come out to play when they have a supportive “host culture.”  AKA: Reddit.Enabling Adolescent BehaviorThis is exactly what Brutsch meant when he told CNN’s Drew Griffin that Reddit “enabled” and “encouraged” his online behavior: “When two years ago, when all of this was at its height, the audience was appreciative, and supportive of the sort of gallows humor that I put out there.” When Brutsch, who is one year shy of 50, said he was catering to an audience of college kids, he means this both literally and figuratively. Brutsch’s fanbase isn’t necessarily college-aged, but the core Internet psyche is.Established sometime between late 1993 and 1999 through sites like Usenet and WebCrawler, and then reborn in 2003 with the creation of 4chan, the Internet psyche is skeptical, self-absorbed, sadistic and lazy – except when it comes to porn, cute animals, digital pranks and acts of Internet vigilantism. For various reasons, perhaps elated to being wealthy, white and privileged, users connected to this hive mind regularly post the most disturbing (re: misogynist, racist) content they can find. You might see this behavior as a way to compensate for, and feel alive in, their mundane real-world existences.    The infamous Usenet troll Ted Frank told Stryker in an interview for his book Epic Win For Anonymous: How 4chan’s Army Conquered The Web, that trolling served as “an educational tool for newcomers.” Modern trolling culture has evolved from its roots on Usenet, however, and Frank “insists” the trolling similarities between 4chan and Usenet are “an etymological coincidence.”  (In fact, the notion of trolling can be traced back even further than Usenet: Stryker describes comedian Andy Kaufman as one of the finest examples of a “pre-Internet troll,” and draws parallels with the “Greek prankster Pan, the Norse god Loki, and the conniving Native American Coyote.”)As the Internet goes mainstream and effectively kills the mantra “there are no girls on the Internet,” older generations, women and traditional media increasingly bump into this hive mind. Their presence will age and mature the digitial pysche just by being there, is the hope.  Facebook is Becoming Less Personal and More Pro… The 4Chan ConnectionMuch of Reddit’s young, trolling psyche comes from 4chan, specifically /b/, but 4chan has managed to stay out of headlines during this flame war. “I don’t understand why everyone was upset at jailbait, while 4chan continually posts bullshit across the internet and no one bats an eye,” wrote redditor he_cried_out_WTF in response to the Violentacrez controversy. “4chan is apparently the petulant child that everyone pretends doesn’t exist as it throws yet another vase on the floor.”Reddit (and 4chan) aren’t the only social news sites that regularly tap into the vase-throwing Internet psyche: Digg, 9gag, Fark, Something Awful, Encyclopedia Dramatica, Buzzfeed, The Daily Dot, Know Your Meme and the entire I Can Haz Cheezburger clan regularly regularly tune in. Even Erik Martin and fellow paid Reddit employees were guilty of listening to this psyche when they cried “free speech” and “privacy” as knee-jerk reactions, when they could have denounced the misogynistic and racist behavior Brutsch catered to.  Brutsch gave the community exactly what it wanted. In return, he heaped up “meaningless Internet points… It had a reward, like the monkey that pushes the button to get a food pellet, it’s addictive” said Brutsch on national television. “Why do people spend money playing [World of Warcraft], why do people play games like that to build up their meaningless stats?, [it’s] exactly the same as 800,000 karma on Reddit.”  Gamification, baby.Where Do The Rest Of Us Fit In?Our reaction, as both journalists and “respectable members of society” prove we’re not that different from Brutsch and the dark side of the Internet. We behaved trollishly when we celebrated his job loss, demanded he be imprisoned or burn in hell, and gleefully discussed how his life is now ruined forever. Our collective outrage – what trolls eat for breakfast – also earned us meaningless Internet points in the form of Facebook likes and Twitter RTs. Chen’s piece made White Knights of us all, but is that enough to fix all the societal ills Brutsch was pointing out with his “trolling?” And is a digital lynching really the way to go? We don’t accept this kind of treatment of criminals in the real world – our current justice system is not ruled by a mob mentality  – but Chen’s piece and the resulting digital lynching is generally viewed as an acceptable means of punishment online. Perhaps, though, the most ironic aspect of this journalist-sanctioned public trial and execution, is that it generated from well-known Reddit “trolls” themselves. last_img read more