SANTA CLARITA – A 19-year-old Valencia man died Sunday after he fell off a freeway overpass while trying to avoid an oncoming car after he had exited his vehicle following a crash, authorities said. California Highway Patrol officers found the body of David Hairston III at 4:50 a.m., about 25 minutes after his Ford Escort collided with a Honda Civic on a rain-soaked northbound Interstate 5 at Gavin Canyon Road. Hairston and a 49-year-old Reseda man had collided, and their vehicles remained in the freeway lanes, police said. Hairston’s vehicle was sideways. Soon after, Phoebe Wong, 55, of Valencia was headed toward the scene and apparently could not see Hairston’s car and hit it, police said. Hairston, who was out of his car, jumped onto the overpass to avoid getting hit by Wong. He then slipped in the wet conditions and fell onto The Old Road below, according to a CHP accident report. Nobody else was seriously injured. 160Want local news?Sign up for the Localist and stay informed Something went wrong. Please try again.subscribeCongratulations! You’re all set!
(Visited 364 times, 1 visits today)FacebookTwitterPinterestSave分享0 It takes a partnership to have a disease, say two microbiologists who argue for ditching the word “pathogen.”Pathogens – disease germs – seem so real, it looks really cranky to claim they don’t exist. Isn’t the Ebola virus a terrible pathogen that doctors are fighting in Africa? But listen to Casadevall and Pirofsky in Nature today:The term pathogen started to be used in the late 1880s to mean a microbe that can cause disease. Ever since, scientists have been searching for properties in bacteria, fungi, viruses and parasites that account for their ability to make us ill. Some seminal discoveries have resulted — such as the roles of various bacterial and fungal toxins in disease. Indeed, our oldest and most reliable vaccines, such as those for diphtheria and tetanus, work by prompting the body to produce antibodies that neutralize bacterial toxins.Yet a microbe cannot cause disease without a host. What actually kills people with diphtheria, for example, is the strong inflammatory response that the diphtheria toxin triggers, including a thick grey coating on the throat that can obstruct breathing. Likewise, it is the massive activation of white blood cells triggered by certain strains of Staphylococcus and Streptococcus bacteria that can lead to toxic-shock syndrome.Disease is one of several possible outcomes of an interaction between a host and a microbe. It sounds obvious spelled out in this way. But the issue here is more than just semantics: the use of the term pathogen sustains an unhelpful focus among researchers and clinicians on microbes that could be hindering the discovery of treatments.Imagine a staph germ just sitting there in the environment. It’s not hurting anyone. It might even have a beneficial function. It’s your fault. It’s your darn body that gets carried away in an overreaction, they seem to be saying. That is certainly a novel way to think about disease germs!Could we find treatments easier by changing our focus from the evil germ to the uncooperative interactions of innocent cells with our bodies? “Context is everything,” Casadevall and Pirofsky argue, providing several examples of how the same microbe can cause different effects in different people. There are clear-cut cases of knocking out the “virulence factors” in tetanus and diphtheria, but success against pneumonia-causing agents has been difficult.Work on vaccines has provided further indications of there being flaws in the idea that discrete factors, akin to toxins, enable all microbes to cause disease. What is more, many of the ongoing attempts to develop new vaccines by identifying and targeting virulence factors have so far proved fruitless. Despite decades of searching, no classical virulence factor suitable for vaccine development has been identified for the tuberculosis bacillus or malaria parasite.What do they suggest? They acknowledge that getting “pathogen” out of the dictionary is not going to happen, but we should recognize the metaphor’s limitations. It’s a “reductionist” approach, they say, to treat the host as a constant and the microbe as a variable. Instead, researchers need to focus more on the host-microbe interaction:New tools are needed to measure the spectrum of inflammatory, biochemical and other forms of damage resulting from the interaction between hosts and microbes. The discovery and development of these tools must be driven by new sessions at conferences, special issues of journals and dedicated funding streams. We think that such a shift in approach would uncover all sorts of possibilities for preventing infectious diseases.Related Health IssuesToxin sharing: A related article in Science Daily talks about “virulence agents” like “microbe toxin genes,” in Lyme disease bacteria, but then shares the surprising news that “Microbe toxin genes have jumped to ticks, mites and other animals.” There seems to be some kind of arms-trade agreement going on. We’re all familiar with the picture of the evil germ injecting its poison into the host, but—Now, in a surprising twist, Mougous and colleagues [U of Washington] have found that many animals have taken a page from the bacterial playbook. They steal these toxins to fight unwanted microbes growing in or on them. The researchers describe their findings in a report to be published online Nov. 24 in the journal Nature.This finding opens the possibility that the enemy of my enemy is my friend, in the internal battle for homeostasis. By horizontal gene transfer, animals can hack the software bacteria use to fight their own enemies. But then, is warfare a proper metaphor at all?How the toxins function in organisms other than ticks remains to be explored. The researchers now are looking at the possibility that other bacterial toxins have been repurposed by animals for antibacterial defense.Toxic fruit: PhysOrg has a story about fruit flies that have adapted to the toxic fruit of a certain tree. All other species of fruit flies are killed by it, but this one species is not repulsed by the odor. “The flies are strongly attracted by the fruits of the morinda tree: they feed on its fruits, and females prefer to lay their eggs on these.” What’s poison to one is food to another.Snake venom: Snakebite: now there’s a really scary situation for humans. Once inside the body, those toxins can wreak havoc on nerves, muscles and tissues, and even cause death. But take a look at the “new model of snake venom evolution proposed” in Science Daily. Maybe the snake wasn’t nefariously plotting to cause us pain.Researchers [at U of Texas] have found genetic evidence that highly toxic venom proteins were evolutionarily ‘born’ from non-toxic genes, which have other ordinary jobs around the body, such as regulation of cellular functions or digestion of food.The researchers are identifying the functions of these toxins “before they evolved into toxins.” Obviously they are not toxic to the snake, who manufactures and stores them. Are snakes just repurposing their original household tools for later needs, like hunting and defense?Castoe said that with an uptick in genetic analysis capabilities, scientists are finding more evidence for a long-held theory. That theory says highly toxic venom proteins were evolutionarily “born” from non-toxic genes, which have other ordinary jobs around the body, such as regulation of cellular functions or digestion of food.“These results demonstrate that genes or transcripts which were previously interpreted as ‘toxin genes’ are instead most likely housekeeping genes, involved in the more mundane maintenance of normal metabolism of many tissues,” said Stephen Mackessy, a co-author on the study and biology professor at the University of Northern Colorado. “Our results also suggest that instead of a single ancient origin, venom and venom-delivery systems most likely evolved independently in several distinct lineages of reptiles.”This thinking meshes a little with the ideas from Casadevall and Pirofsky: it’s misleading to consider snake venom a “pathogen” of sorts. We must focus on the interaction of the substance within the host body. Those genes would tend to become more expressed at higher levels—up to a point:Based on their data, the new paper presents a model with three steps for venom evolution. First, these potentially venomous genes end up in the oral gland by default, because they are expressed in low but consistent ways throughout the body. Then, because of natural selection on this expression in the oral gland being beneficial, tissues in the mouth begin expressing those genes in higher levels than in other parts of the body. Finally, as the venom evolves to become more toxic, the expression of those genes in other organs is decreased to limit potentially harmful effects of secreting such toxins in other body tissues.This is not Darwinian natural selection; it’s just adjustment of existing genetic information (how much it is expressed, and in what tissues). The snakes don’t want to shoot themselves in the foot! (Note: snakes do not have feet.) Snakes are not evil sinners, but some evolutionary models are:The team calls its new model the Stepwise Intermediate Nearly Neutral Evolutionary Recruitment, or SINNER, model. They say differing venom levels in snakes and other animals could be traced to the variability of where different species, or different genes within a species, are along the continuum between the beginning and end of the SINNER model….“What is a venom and what species are venomous will take a lot more evidence to convince people now,” Castoe said. “It provides a brand new perspective on what we should think of when we look at those oral glands.”What all these stories have in common is the repurposing of existing genetic information as interactions between organisms are explored in various environments.We offer these news items to creation ecologists who would like to consider possible avenues for the origin of “natural evil.” The Curse as described in Genesis 3 may not have involved creation of harmful agents de novo. Instead, it may have involved minor adjustments to existing structures, or relaxation of controls on the maintenance of structures, or relaxation of controls on interactions between organisms. Instead of a controlled, harmonious ecosystem, it became a more chaotic ecology, with organisms getting by as best they could, within certain constraints (God’s continuing care for His creation). Anyway, these are new and interesting ways to think about the issues.
The South African Cabinet is to appoint a team of officials from the ministries of minerals and energy, water affairs and forestry, public enterprises and trade and industry to develop a comprehensive Electricity Master Plan for the country.In a statement released on Wednesday 21 November, government chief spokesman Themba Maseko said that cabinet’s decision followed the presentation of a draft Electricity Master Plan which showed the rise in demand for energy caused by the high rate of economic growth and South Africa’s continued reliance on coal as an energy source.South Africa has been experiencing rolling blackouts over the past few years as demand outstrips supply.The comprehensive Electricity Master Plan will include increasing capacity and improving the reliability of the electricity infrastructure, providing reasonably priced electricity, ensuring security of supply as set out in the security of supply standards, diversifying energy sources and meeting the renewable energy targets.The investment in maintenance and rehabilitation of infrastructure and the quality of supply of electricity will be regulated in future, the statement said.It’s expected that this plan will enable the government to make the correct investment decisions to meet South Africa’s extensive energy requirements as the economy continues to grow.Some of the strategic considerations will include the skills development and management; the need for investment in research and technology and meeting demands that are a result of the rise in fixed capital formation by both the public and private sectors, including economic activities associated with the 2010 Fifa World Cup.In the meantime, the Maseko said, Eskom’s investment strategy to increase the generation capacity and local government investments in maintenance of existing infrastructure will continue and will form part of the comprehensive Electricity Master plan.The final plan will be finalised and approved next year.Useful links SA Government: www.gov.zaEskom: www.eskom.co.za
The Enforcement Directorate informed a Delhi court on Wednesday that it has summoned Ratul Puri, nephew of Madhya Pradesh Chief Minister Kamal Nath, for interrogation in a money laundering case related to the AgustaWestland VVIP chopper scam. ED told Special Judge Arvind Kumar that Mr. Puri, Chairman of Hindustan Powerprojects Pvt Ltd, was summoned for confronting him with Sushen Mohan Gupta, an arrested middleman in the case, whose custodial interrogation was on Wednesday extended by three more days by the court. Seeking the extension of Mr. Gupta’s custody, ED told the court that he was required to be confronted with various people including Mr. Puri in the case pertaining to the now scrapped ₹3,600 crore chopper deal. Mr. Puri, who was summoned to join the probe on Wednesday, denied having “any connection or involvement of any kind in defence or the case”.In a statement, his company said: “He would be fully cooperating with the ED investigation and provide any clarification or information as may be required.” Middleman’s statementAccording to ED sources, Mr. Puri’s name appeared in the statement recorded by middleman and Dubai-based businessman Rajeev Saxena, who recently turned approver in the case. ED’s special public prosecutors D.P. Singh and N.K. Matta also told the court that the agency wanted to identify one “RG”, in whose name entries of over ₹50 crore were made in Mr. Gupta’s diaries.“The custodial interrogation of Gupta is required as he is misguiding the probe by deliberately giving wrong explanation of abbreviations in his diaries wherein abbreviation ‘RG’ finds mention in many pages as well as pen drive data.“More than ₹50 crore shown to have been received from ‘RG’ between 2004 to 2016, whereas the ‘RG’ identified by Mr. Gupta, i.e., Rajat Gupta, had admitted to have cash transactions with Sushen from 2007 onwards and the same are being quantified,” the agency told the court. The agency submitted that Sushen said he only knew one ‘RG’ who was Rajat Gupta, whereas Rajat denied the transactions made in the name of RG and said he not the person being referred to.
It might have been rejected by the ICC but Sachin Tendulkar’s suggestion to revamp the ODIs by splitting the format into four innings of 25 overs each has got the backing of his Test teammate Rahul Dravid.”It is interesting (suggestion). I don’t know why the ICC has rejected it (Tendulkar’s suggestion via a letter to ICC), but it’s a good idea that Sachin has given and is worth experimenting,” said India’s batting mainstay on the England tour on the sidelines of a promotional event for ‘Gillette’ here last night.”It has been tried out in Australia (in domestic cricket) and the plus and minus points should be looked into,” he added.Tendulkar had written a letter to the ICC to change the format of the ODIs from two innings of 50 overs to four of 25 overs like a Test match but the world council’s Chief Executive Haroon Lorgat had rejected it.”There is no need to change the format,” Lorgat told reporters in Colombo on Wednesday.”We did receive a written proposal from Sachin, but that was a long time back. I myself have spoken to him many times about it, the last one as recent as during the World Cup in April.The success of the tournament showed that the 50-over format was sound in health and there was no need for dramatic changes,” Lorgat added.”The executive board meeting after the World Cup decided that the present format was doing well. That has not changed,” Lorgat stressed.Tendulkar had argued that four innings of 25 overs would be a fair way to balance the advantage gained by the team which won the toss in conditions such as bad weather, sub-quality pitches which historically had proven that a match can virtually be decided by the toss of a coin.advertisementDravid also backed the Cricket Board for deciding to put pressure on the ICC for revising the controversial Decision Review System of which he got the rough end of the stick in the Test and ODI rubbers in England.”It’s not set in stone. Anything connected with DRS is a work in progress. There are new challenges and questioned about it. Its up to the member boards (of the ICC) to ask whether things are better with it in place,” said the 39-year-old Dravid.Dravid, who was the lone batsman to show consistently superb form in difficult conditions against a top class England pace attack in the four-match Test rubber that India lost 0-4, was also controversially given out through the ‘Hot Spot’ image system on at least three occasions leading to big debates over DRS.
Coimbatore, Sept 22 (PTI): Three fully grown sandalwood trees were axed and taken out by some persons from a private farm at Podanur here, police said. Shanmugam, who was growing three 20 foot tall sandalwood trees, notice the axed trees when he went to his farm this morning. Based on his complaint, a case was registered, police said. Some days back, two sandalwood trees had been axed from the roadside at Race Course area in the heart of the city. An alert security guard of a star hotel there had prevented the miscreanst from taking it away. PTI NVM APR APR
zoomImage Courtesy: Royal Niestern Sander/Flying Focus Dutch shipowner and operator Wagenborg has ordered a second EasyMax type carrier from compatriot builder Royal Niestern Sander.The new vessel is scheduled to start construction soon, according to an announcement from Royal Niestern Sander.The open-top, ice-classed vessel will be a future sister ship to the Egbert Wagenborg, which started operations in 2017.Developed by Wagenborg and Niestern Sander, the 149-meter-long EasyMax concept is a Handysize multi-purpose vessel with a load capacity of 14,000 tons and a hold capacity of 625,000 cft.Egbert Wagenborg is also the largest vessel ever built by Royal Niestern Sander shipyard.Thanks to its low resistance due to optimal hull shape, the vessel consumes 9 tonnes of fuel a day at 11 knots, according to Wagenborg.
00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave SettingsSAN DIEGO (KUSI) – 82 year old Judy Wilson has lived in her home in Chula Vista for 45 years, calling it her peaceful sanctuary.For years now there have been talks about building a car wash right beneath her home, 43 feet away from her back fence.It might look like an empty parking lot right now, but the plan calls for a 2,400 square foot building with an 85 foot long car wash tunnel. That includes 12 vacuum stations in the parking lot.“The noise coming out of that is like an airplane revving up at Lindbergh Field it is so loud” says Wilson.She’s concerned about the noise, the traffic and most importantly her health, because she’s toxic sensitive. There used to be a gas station here and she says it could have contaminated the soil beneath it.“When I get hit with something like that, it closes up my throat, I can barely breathe, I ache in every part of my body and I just can’t function right.”Neil Capin, the owner of the proposed car wash, says he’s gone above and beyond to address these concerns. He’s willing to install a sound wall up, add vegetation and landscaping to soften the noise, and even open an hour later every day.City leaders gave the car wash a stamp of approval but challenges and appeals quickly followed. Tonight Chula Vista City Council voted 4-1 against the car wash’s construction. January 22, 2019 Chula Vista residents win battle over new car wash , Posted: January 22, 2019 Categories: Local San Diego News FacebookTwitter
Kolkata: The BJP on Friday moved an appeal before a division bench of the Calcutta High Court against refusal of permission for its Rath Yatra. Granting leave to the BJP to file the appeal, a division bench comprising Justices B Somadder and A Mukherjee said it will hear the matter at 12.30 pm. The bench directed BJP’s lawyers to serve copy of the appeal to the West Bengal government and other respondents before the matter is taken up for hearing. Also Read – Rain batters Kolkata, cripples normal life A single bench of the high court on Thursday said it cannot grant permission at this stage for the BJP rally in Coochbehar, scheduled to be flagged off by party president Amit Shah on Friday, after the West Bengal government refused to allow the event on the grounds that it might cause communal tension. The court directed that superintendents of police of all districts in West Bengal will file a report by December 21 to it on the holding of ‘rath yatra’ rallies by the Bharatiya Janata Party (BJP), after hearing all district presidents of the party. Directing that the rally stands deferred till the next date of hearing on January 9, Justice Tapabrata Chakraborty observed that the prayer of BJP for permission to hold the Rath Yatra cannot be granted at this stage.
Posted by Share Friday, October 14, 2016 << Previous PostNext Post >> Gourmet ganja? Marijuana dining latest tourism trend The Canadian Press LYONS — How to set a tone of woodsy chic at a four-course candlelight dinner served under the stars in the Colorado foothills:Live musicians and flowers, check.Award-winning cuisine, check.Beer and wine pairings with each course, check.Marijuana pairings? Oh, yes.The 100 diners at this $200-a-plate dinner smoked a citrus-smelling marijuana strain to go with a fall salad with apples, dates and bacon, followed by a darker, sweeter strain of pot to accompany a main course of slow-roasted pork shoulder in a mole sauce with charred root vegetables and rice.And with dessert? Marijuana-infused chocolate, of course, grated over salted caramel ice cream and paired with coffee infused with non-intoxicating hemp oil.The diners received small glass pieces and lighters to smoke the pairings, or they could have their marijuana rolled into joints by professional rollers set up next to a bartender pouring wine.Welcome to fine dining in Weed Country.The marijuana industry is trying to move away from its pizza-and-Doritos roots as folks explore how to safely serve marijuana and food. Chefs are working with marijuana growers to chart the still-very-unscientific world of pairing food and weed. And a proliferation of mass-market cheap pot is driving professional growers to develop distinctive flavours and aromas to distinguish themselves in a crowded market.More news: TRAVELSAVERS welcomes Julie Virgilio to the team“We talk with the (marijuana) grower to understand what traits they saw in the marijuana … whether it’s earthy notes, citrus notes, herbal notes, things that we could play off,” said Corey Buck, head of catering for Blackbelly Restaurant, a top-rated farm-to-table restaurant that provided the meal.The grower of one of the pot strains served at the dinner, Alex Perry, said it won’t be long until marijuana’s flavours and effects are parsed as intently as wine profiles. But that’s in the future, he conceded.“It’s still looked down upon as a not-very-sophisticated thing,” said Perry, who grew a strain called Black Cherry Soda for his company, Headquarters Cannabis.Holding his nose to a small jar of marijuana, Perry said, “If I asked my mom or my dad what they smell, they’re going to say, ‘skunk,’ or, ‘It smells like marijuana.’ But it’s like wine or anything else. There’s more flavour profile there.”This is just the latest trend in the booming pot industry where travel and wellness trends often intertwine.